Orion may refer to:
- Orion (constellation), a constellation
- Orion Arm, a spiral arm in the Milky Way galaxy
- Orion Nebula, a nebula also known as M42
- Orion (US rocket), an American sounding rocket
- Orion (Argentine rocket), an Argentine sounding rocket
- Orion (spacecraft), a U.S. space capsule in development by Lockheed Martin, previously called the Crew Exploration Vehicle
- Orion, the lunar module of the Apollo 16 manned mission to the moon
- Project Orion, a proposed nuclear pulse propulsion system for spacecraft